MIAL

Small Animal Image Analysis

Principal Investigator: Ghassan Hamarneh

We are developing tools for segmentation, registration, and shape analysis of small animal images for genotype-phenotye studies. The long term goal of this work is the description of structural shape variations in normal, genetically identical mice and the subsequent detection of pathological phenotypes in genetically modified mice.


Noise reduction using anisotropic diffusion filtering

Segmentation using deformable surface (simplex mesh) model.

Segmentation result shown on 2D slices.

Displacement field for registering mice brains.

Local volume change calcualtion.

Combining anatomy-dependent spatial transformations for MR mouse body registration

Registering mouse head to target by changing its posture





G. Hamarneh, J. Chen, B. Neiman, J. Henderson, M. Henkelman. “Segmentation, Registration, and Deformation Analysis of 3D MR Images of Mice”. Medical Image Computing and Computer-Assisted Intervention, 2003, Lecture Notes in Computer Science, ISBN 3-540-20464-4, vol. 2879, pp. 878-885.

N. Kovacevic, G. Hamarneh, M. Henkelman, “Anatomically Guided Registration of Whole Body Mouse MR Images”. Medical Image Computing and Computer-Assisted Intervention, 2003, Lecture Notes in Computer Science, ISBN 3-540-20464-4, vol. 2879, pp. 870-877.

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