MIAL

Vinay Kotamraju successfully defended his MSc thesis

March 6, 2008
Congratulations to Vinay Kotamraju. He successfully defended his MSc Thesis today (Thursday, Mar. 6th, 2008).

Senior Supervisor: Mirza Faisal Beg
Supervisory Committee: Elliot McVeigh, Ghassan Hamarneh.

Title of Vinay's thesis: Tagged MR Image Analysis for Estimation and Statistical Analysis of Myocardial Motion and Strain

Abstract:

Cardiovascular diseases (CVDs) continue to be the leading cause of death in the western world. The ability to quantify cardiac function in-vivo, both within and across subjects, has the potential to provide an important tool to signal the presence of life threatening CVDs. Deriving and comparing intra-myocardial contractile properties accurately, meaningfully and throughout the cardiac cycle using tagged Magnetic Resonance Imaging (MRI), a novel and promising imaging modality, has proven to be a challenging problem.

This thesis presents algorithms for the estimation and statistical analysis of myocardial motion and strain from Tagged MRI. Towards this, we develop an end to end semi-automated algorithmic pipeline to perform (1) automated and sub-pixel accurate myocardial motion estimation using diffeomorphic non-rigid registration, (2) dense validation of estimated motion using novel synthetic data based ground truth generation, (3) quantitative comparison of left ventricular (LV) strains across subjects via sub-pixel accurate inter-subject registration, and, (4) exploratory analysis of LV strains using PCA. In addition, we also present a high dimensional inter-slice interpolation algorithm to deal with low-resolution image volumes during inter-subject registration.

More details on Vinay's work can be found here.


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