Vinay Kotamraju successfully defended his MSc thesis

March 6, 2008
Congratulations to Vinay Kotamraju. He successfully defended his MSc Thesis today (Thursday, Mar. 6th, 2008).

Senior Supervisor: Mirza Faisal Beg
Supervisory Committee: Elliot McVeigh, Ghassan Hamarneh.

Title of Vinay's thesis: Tagged MR Image Analysis for Estimation and Statistical Analysis of Myocardial Motion and Strain


Cardiovascular diseases (CVDs) continue to be the leading cause of death in the western world. The ability to quantify cardiac function in-vivo, both within and across subjects, has the potential to provide an important tool to signal the presence of life threatening CVDs. Deriving and comparing intra-myocardial contractile properties accurately, meaningfully and throughout the cardiac cycle using tagged Magnetic Resonance Imaging (MRI), a novel and promising imaging modality, has proven to be a challenging problem.

This thesis presents algorithms for the estimation and statistical analysis of myocardial motion and strain from Tagged MRI. Towards this, we develop an end to end semi-automated algorithmic pipeline to perform (1) automated and sub-pixel accurate myocardial motion estimation using diffeomorphic non-rigid registration, (2) dense validation of estimated motion using novel synthetic data based ground truth generation, (3) quantitative comparison of left ventricular (LV) strains across subjects via sub-pixel accurate inter-subject registration, and, (4) exploratory analysis of LV strains using PCA. In addition, we also present a high dimensional inter-slice interpolation algorithm to deal with low-resolution image volumes during inter-subject registration.

More details on Vinay's work can be found here.

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